Laboratory Professionals Member Community

An O Neg woman has a Positive screen. Upon PTRC, she got a dose of RHIG a month earlier. What type of XM would you adopt for a unit of PC?
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This is a very common cause of a transient positive screen. I am on the academic end and have not been in the lab for a while, but I assume the following course of action is reasonable with the limited information that is available. 

1. Issue ABO-identical (O) platelets.
2. Rh-negative platelets for an Rh-negative woman of childbearing potential. If only Rh-positive platelets are available, they may be given with RhIG prophylaxis.

It would be interesting to know what the actual course of action was and how the case was resolved. Thank you,

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Payman Nasr, PhD, MT ASCP
Professor and Chair
California State University, Dominguez Hills
Carson, CA 90747
310-243-3082
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Since the positive antibody screen is attributed to passive anti-D from recent RhIG administration, this antibody is not considered clinically significant for transfusion reactions.

For platelet transfusion, most institutions do not perform AHG crossmatching. The priority would be to provide ABO-compatible and Rh-negative platelets, especially in a female of childbearing potential.

An immediate-spin or electronic crossmatch, if performed, would generally be sufficient. Policies may vary by institution, but AHG crossmatch is typically reserved for clinically significant alloantibodies rather than passive anti-D. Interested in how different labs approach this.

Thank you 

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Sukanya Madan Mohan 
Fort Wayne IN

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